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Using TNF- as a measurement of pro-inflammatory signaling, we determined that LTB4 addition in a pro-inflammatory environment augments pro-inflammation in both MINOCA and MI (Fig

In Nlgn3 -KO mice, administration of the OXTR antagonist L-368,899 reduced social interactions, confirming that inhibition of oxytocinergic signaling impairs sociability [37]

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Since it is hard to obtain clinical samples in overdose cases that control the many genetic and environmental variables that can affect protein expression, it is often easier to discover proteomics biomarkers in nonclinical toxicity studies and then set up clinical sample collection strategies to further evaluate the potential toxicity biomarkers